Table 1:
Demographics and case characteristics for analysis of tauopathies.
| Diagnosis | n | Age (mean, sd) | Female (n, %) | PMI (mean, sd) | CDR (median, IQR) | ABC Score |
|---|---|---|---|---|---|---|
| HCa | 5 | 78, 10 | 5, 100% | 8.2, 2.4 | 0, 0 |
A0B1C0 (1) A1B1C0 (2) A1B1C1 (1) A2B0C0 (1) |
| AD | 5 | 66, 5 | 2, 40% | 8.6, 0.9 | 3, 0 | A3B3C3 (5) |
| AGD | 5 | 84, 12 | 1, 20% | 8.7, 4.1 | 0.5, 0 | A?B1C1 (1) A?B2C1 (1) A0B2C0 (1) A1B2C0 (2) |
| CBD | 5 | 66, 4 | 2, 40% | 9.3, 2.7 | 1, 2.5 | A1B1C0 (5) |
| PiD | 5 | 68, 8 | 2, 40% | 10.2, 3.9 | 3, 0 |
A0B0C0 (1) A1B0C0 (1) A1B1C0 (2) A1B0C1 (1) |
| PSP | 5 | 76, 10 | 3, 60% | 11.1, 4.9 | 0.5, 0 |
A0B0C0 (1) A0B1C0 (3) A1B1C0 (1) |
| Total | 30 | 73, 10 | 15, 50% | 9.3, 3.3 | 0.75, 2.5 |
A0B0C0 (2) A0B1C0 (4) A0B2C0 (1) A1B0C0 (1) A1B0C1 (1) A1B1C0 (10) A1B1C1 (1) A1B2C0 (2) A2B0C0 (1) A3B3C3 (5) A?B1C1 (1) A?B2C1 (1) |
a
One of the HC cases had inclusions of α-synuclein in the form of Lewy bodies in the brain stem; however, none noted in the cortex.
Abbreviations: HC, Healthy Controls; AD, Alzheimer’s disease; AGD, Argyrophilic Grain Disease; CBD, Corticobasal Degeneration; PiD, Pick’s disease; PSP, Progressive Supranuclear Palsy; PMI, Postmortem Interval; CDR, Clinical Dementia Rating