. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: Acta Neuropathol. 2021 Mar 7;141(5):651–666. doi: 10.1007/s00401-021-02279-2

Table 4:

Proportions (mean, sd) of each Rhes phenotype with PHF-1+ tau inclusions by region.

		Diffuse Rhes		Punctiform Rhes		Absent Rhes
	Dx	PHF-1+	PHF-1−	PHF-1+	PHF-1−	PHF-1+	PHF-1−	p-value^a
a) Entorhinal cortex	Total (n=30)	0.043, 0.073	0.957, 0.073	0.726, 0.323	0.274, 0.323	0.919, 0.188	0.081, 0.188	< 0.0001^b
a) Entorhinal cortex	HC (n=5)	0.01, 0.011	0.99, 0.011	0.556, 0.509	0.444, 0.509	0.889, 0.192	0.111, 0.192	0.0737
	AD (n=5)	0.074, 0.036	0.926, 0.036	0.688, 0.187	0.312, 0.187	0.96, 0.089	0.04, 0.089	0.0024
	AGD (n=5)	0.006, 0.009	0.994, 0.009	0.444, 0.509	0.556, 0.509	0.587, 0.361	0.413, 0.361	0.0693
	CBD (n=5)	0.004, 0.006	0.996, 0.006	0.675, 0.395	0.325, 0.395	1, 0	0, 0	0.0061
	PiD (n=5)	0.154, 0.118	0.846, 0.118	0.913, 0.092	0.087, 0.092	0.98, 0.045	0.02, 0.045	0.0049
	PSP (n=5)	0.008, 0.009	0.992, 0.009	0.927, 0.12	0.073, 0.12	1, 0	0, 0	0.0103

b) Cornu Ammonis 1	Total (n=30)	0.074, 0.171	0.926, 0.171	0.841, 0.25	0.159, 0.25	0.936, 0.149	0.064, 0.149	< 0.0001^b
b) Cornu Ammonis 1	HC (n=5)	0.01, 0.018	0.99, 0.018	0.508, 0.45	0.492, 0.45	1, 0	0, 0	0.0586
	AD (n=5)	0.067, 0.102	0.933, 0.102	0.833, 0.078	0.167, 0.078	0.992, 0.017	0.008, 0.017	0.0016
	AGD (n=5)	0.001, 0.003	0.999, 0.003	0.917, 0.167	0.083, 0.167	0.833, 0.289	0.167, 0.289	0.0107
	CBD (n=5)	0.011, 0.013	0.989, 0.013	1, 0	0, 0	NA^c	NA^c	0.0486
	PiD (n=5)	0.345, 0.294	0.655, 0.294	0.965, 0.052	0.035, 0.052	0.894, 0.157	0.106, 0.157	0.0145
	PSP (n=5)	0.011, 0.018	0.989, 0.018	0.778, 0.385	0.222, 0.385	1, 0	0, 0	0.0392

c) Superior frontal gyrus	Total (n=25)	0.028, 0.038	0.972, 0.038	0.567, 0.395	0.433, 0.395	0.851, 0.357	0.149, 0.357	< 0.0001^b
c) Superior frontal gyrus	HC (n=5)	0, 0	1, 0	0, 0	1, 0	0, 0	1, 0	NA^d
	AD (n=5)	0.056, 0.047	0.944, 0.047	0.764, 0.12	0.236, 0.12	0.8, 0.447	0.2, 0.447	0.0365
	CBD (n=5)	0.014, 0.013	0.986, 0.013	0.413, 0.433	0.587, 0.433	0.775, 0.437	0.225, 0.437	0.1765
	PiD (n=5)	0.065, 0.043	0.935, 0.043	0.816, 0.215	0.184, 0.215	1, 0	0, 0	0.0023
	PSP (n=5)	0.005, 0.003	0.995, 0.003	0.625, 0.479	0.375, 0.479	1, 0	0, 0	0.0163

p-value computed by a Kruskal-Wallis rank sum test comparing the PHF-1+ proportions in each Rhes phenotype for each disease.

p-value for all diseases combined computed using a one-way ANOVA comparing the PHF-1+ proportions in each Rhes phenotype

No CA1 neurons with the absent Rhes phenotype were detected in CBD cases

The Kruskal-Wallis rank sum test cannot estimate the significant of data lacking variance

Abbreviations: HC, Healthy Controls; AD, Alzheimer’s disease; AGD, Argyrophilic Grain Disease; CBD, Corticobasal Degeneration; PiD, Pick’s disease; PSP, Progressive Supranuclear Palsy