Table 5:
Proportions of tau inclusion positive CA1 neurons classified as each Rhes phenotype for different post-translational modifications of tau.
| Antibody | Epitope | Diffuse Rhes | Punctiform Rhes | Absent Rhes |
|---|---|---|---|---|
| PHF-1a | phospho-Ser396, Ser404 Tau | 5.99% | 61.08% | 32.93% |
| 1f3c | acetyl-Lys274 Tau | 10.42% | 29.17% | 60.42% |
| AT100 | phospho-Thr212, Ser214 Tau | 8.46% | 55.38% | 36.15% |
| Tau-C3 | ΔAsp421 Tau | 4.11% | 35.62% | 60.27% |
| MC1 | Conformational tau | 5.69% | 60.98% | 33.33% |
a
While calculated from the same two AD cases as the other tau post-translational modifications, PHF-1 was calculated from one large 1×1mm counting frame instead of the three 650×650μm counting frames used for the other post-translational modifications.