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. 2021 Jun;22(6):1827–1836. doi: 10.31557/APJCP.2021.22.6.1827

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Effect of CCA-1.1 on Cell Migration. The 4T1 and MCF-7/HER2 cells were scratched then treated with CCA-1.1 at indicated concentration alone and in combination with Doxorubicin (Dox). The morphology of the 4T1 cells (A) and MCF-7/HER2 cells (B) after scratched and treated with the compounds under an inverted microscope with magnification of 100x. The percentage of 4T1 cells (C) and MCF-7/HER2 cells (D) closure after treatment. The area of closure was measured using ImageJ (n=3) and % closure was calculated. The asterisk (*) indicate statistical difference compared to % closure of control (untreated cells) at the same hour of observation (p<0.05)