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. 2021 Sep 6;15(6):899–909. doi: 10.1016/j.pcd.2021.08.014

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© 2021 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — Pathophysiological mechanisms of COVID-19 with diabetes. Red boxes/lines/arrows represent diabetes and its impacts; purple boxes/lines/arrows represent SARS-CoV-2 and its impacts; orange boxes represent enzymes related to the virus invasion; blue boxes represent the renin-angiotensin system (RAS). ACE: angiotensin-converting enzyme; TMPRSS2: transmembrane protease serine 2 (for interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).