Table 4.
Risk factors for ESKD in the long term among patients with pauci-immune glomerulonephritis who responded to initial immunosuppressive therapy and achieved remission by the end of the first year
| Variable (at diagnosis) | Hazard ratio (95% CI) | P value |
|---|---|---|
| Multivariable model | ||
| Low serum C3 | 1.99 (0.51–7.70) | 0.31 |
| Serum creatinine | 1.31 (1.03–1.66) | 0.02 |
| Normal glomeruli >10% (versus ≤10%) | 0.61 (0.13–2.85) | 0.53 |
| EUVAS category | ||
| Focal class versus sclerotic class | 0.06 (0.005–0.75) | 0.03 |
| Crescentic class versus sclerotic class | 0.44 (0.08–2.39) | 0.34 |
| Mixed class versus sclerotic class | 0.62 (0.11–3.40) | 0.6 |
| Interstitial fibrosis (moderate or severe versus none/mild) | 1.06 (0.28–4.01) | 0.92 |
| RBC casts present in specimen | 0.11 (0.01–0.66) | 0.01 |
CI, confidence interval; ESKD, end-stage kidney disease; GFR, glomerular filtration rate; RBC, red blood cell; EUVAS, European Vasculitis Society.