(a) Urinary protein/creatinine ratio, (b) serum albumin, and (c) estimated glomerular filtration rate at baseline and throughout study course. (d) Representative plots for CD4+CD25+CD127LOW T regulatory cells (TREG) at baseline and at 12 months posttreatment; (e) quantification of circulating TREG; (f) total CD4+ T cells, and (g) TREG/CD4+ T cell ratio at baseline and throughout study. Data are represented as median ± interquartile range. P/C, urinary protein/creatinine ration; TREG, regulatory T cells. ∗P < 0.05 versus month 0.