Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of PAPRPi in cancer. PARP: Poly (ADP-ribose) polymerase HRR: Homologous recombination repair. PARP is a key protein in repairing single-strand DNA breaks. If the cell has lost PARP function then the single-strand breaks accumulate leading to double-strand DNA breaks. If the HRR repair pathway is nonfunctional then the cell undergoes apoptosis.
