Table 2:
Olaparib (N = 256)[2, 9] | Rucaparib (N = 115)[10] | |||
---|---|---|---|---|
Adverse Event | All Grades (%) | Grades ≥ 3 (%) | All Grades (%) | Grades ≥ 3 (%) |
Anemia | 199 (46) | 55 (21) | 50 (43.5) | 29 (25.2) |
Anorexia | 77 (30) | 3 (1) | 32 (27.8) | 2 (1.7) |
Asthenia/Fatigue | 104 (41) | 7 (3) | 71 (61.7) | 10 (8.7) |
Creatinine elevation[8] | 9 (18%) | 0 (0) | 18 (15.7) | 1 (0.9) |
Diarrhea | 54 (21) | 2 (<1) | 23 (20.0) | 0 |
Nausea | 106 (41) | 3 (1) | 60 (52.2) | 3 (2.6) |
Neutropenia | NR | 10 (3.9) | 12 (10.4) | 8 (7.0) |
NR Not reported