Table 5.

Reclassification Analyses for Prognostic Value of Urinary and Plasma CNP Levels for Clinical Outcomes in ADHF Patients

Model	C-statistic	IDI (95% CI)	Relative IDI (95% CI)	P value
Rehospitalization/Death
Base model	0.59 (0.54, 0.63)
Base model + uCNP/pCNP groups	0.60 (0.56, 0.65)	0.028 (0.003, 0.079)*	46.5% (0.2%, 174.0%)*	0.005*
Base model + NT-proBNP	0.60 (0.55, 0.64)
Base model + NT-proBNP + uCNP/pCNP groups	0.61 (0.56, 0.65)	0.022 (0.001, 0.072)#	30.0% (0.0%, 115.0%)#	0.01#
Rehospitalization
Base model	0.59 (0.53, 0.64)
Base model + uCNP/pCNP groups	0.60 (0.55, 0.65)	0.034 (0.003, 0.095)*	49.1% (0.2%, 185.0%)*	0.004*
Base model + NT-proBNP	0.59 (0.54, 0.65)
Base model + NT-proBNP + uCNP/pCNP groups	0.61 (0.55, 0.66)	0.036 (0.004, 0.103)#	45.8% (0.6%, 164.0%)#	0.004#

Base model included age, sex, eGFR, urinary protein/creatinine ratio and LVEF.

uCNP/pCNP groups, the 4 subgroups based on urinary and plasma CNP levels as indicated in Table 3 and Table 4.

^*IDI analyses compared to base model

^#IDI analyses compared to base model + NT-proBNP; the 95% CIs and P values were calculated based on 1000 bootstrap samples.

IDI = integrated discrimination index; CI = confident interval.