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. 2021 Aug 7;11(18):8706–8737. doi: 10.7150/thno.57004

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A Schematic illustration of the mechanism of the pH-sensitive nanotheranostic system. (SPIO: superparamagnetic iron oxide nanocrystals, SA: stearic acid, PEI: polyethylenimine, HHPA: hexahydrophthalic anhydride, SPA: hexahydrophthalic anhydride modified stearic acid-grafted polyethylenimine. B Time-lapse NIR images of mice treated with IR780, SP-SPIO-IR780 or SPA-SPIO-IR780 nanosystems, respectively. C MRI (colour mapping) of the tumour site before and 24 hours post injection of SP-SPIO-IR780 and SPA-SPIO-IR780, 3.0 T. Adapted with permission from ¹¹⁶, copyright 2013 Royal Society of Chemistry.