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. 2021 Jul 31;11(18):8640–8659. doi: 10.7150/thno.61833

Figure 4.

Figure 4

Transient CSF1R blockade after lateral spinal cord hemisection in nonhuman primate decreases microglia proliferation. Fluorescent micrographs of axial spinal cord sections from untreated (A-C) and GW2580-treated (D-F) Microcebus murinus at 1 week after SCI. All images were taken on the contralateral side 5 mm rostral to the lesion epicenter. IBA1 staining (A & D), BrdU staining (B & E) and merged (C & F). Arrows (C & F) indicate proliferative microglia (BrdU+/IBA1+). Scale bar: 50µm. Number of Microcebus murinus analyzed: n = 3 for untreated and n = 3 for treated animals.