Table 2.

Summary of clinically relevant oncology informations provided by different imaging modalities to guide, monitor and evaluate Photodynamic Therapy responses in preclinical and clinical settings.

Imaging Modality	Pre and Post treatment Information
Endoscope-coupled FL, US, OCT	Tumor localization in hollow tube organs
CT	Tumor localization Necrosis and surviving tumor volume
MRI	Tumor volume Necrosis and histopathological analysis Vascular perfusion and permeability
PET	Tumor volume and localization Tumor hypoxia Necrosis and surviving tumor volume
OCT	Microscopic resolution of Tumor volume and margin delineation of superficial tumors
Laser Doppler imaging and Angiography	Vascular perfusion and blood flow velocity
OI	FL based PS uptake and photobleaching mediated treatment response Singlet oxygen luminescence (SOL)
US	Tumor volume and localization Necrotic and apoptotic tumor fraction Vascular density, perfusion and blood flow velocity Image-guided fiber placement
PAI	Vascular structure and density PS uptake and distribution PS photobleaching rate Dynamics of blood oxygen saturation and partial pressure of oxygen

PET: Positron Emission Tomography; SPECT: Single-Photon Emission Computerized Tomography; CT: Computed tomography; MRI: Magnetic Resonance Imaging; US: Ultrasound Imaging; FL: Fluorescence Imaging, OI: Optical Imaging; OCT: Optical Coherence Tomography; PAI: Photoacoustic Imaging; PS: Photosensitizer.