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Therapeutic strategies for enhancing tissue regeneration of PGE2. (A) Inhibiting the activity via several small molecular compounds of 15-PGDH prevents PGE2 from degradation. (B) Modifying the PGE2 molecule to change its spatial structure or dehydrogenation site can resist the metabolism of 15-PGDH without changing the activity of PGE2. (C) Strategies for controlling release of PGE2 from biomaterials.
