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. 2021 Aug 25;11(18):9009–9021. doi: 10.7150/thno.59728

Figure 2.

Figure 2

DIABLO/SMAC mimetic loaded TNP preferentially induce cell death in HIV-1-infected cells. Mock- and HIV-1-infected TCM (A, C) or macrophages (B, D) were exposed to vehicle, empty TNP (TNP) or DIABLO/SMAC mimetic loaded TNP (LCL-161/LCL or AT-406/AT) for 4 h, washed three times with PBS, and then incubated for a further 24 h in fresh media. n = 4. (A, B) Left, representative western blots of BIRC2, XIAP and ACTB. Right, densitometric analysis of blots. (C, D) Aliquots of supernatants were spectrophotometrically tested for LDH as a measure of cell death.