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. 2021 Jul 25;11(18):8624–8639. doi: 10.7150/thno.48561

Figure 2.

Figure 2

Effects of Ang IV on myocardial morphology, fibrosis and apoptosis in 5 groups of mice. (A) Representative images of H&E staining, TEM, and Masson's trichrome staining of the myocardium in 5 groups of mice. (B) Quantification of mitochondrial size, mitochondrial number per field, CVF and PVCA/LA in 5 groups of mice. (C) Representative immunohistochemical staining of Col I, Col III, and TUNEL in the myocardium of 5 groups of mice. (D) Quantification of immunohistochemical staining of Col I, Col III, and TUNEL in the myocardium of 5 groups of mice. (E) Representative Western blot images of Col I, Col III, TGF-β1, Bax, Bcl-2 and Cl-caspase3 expressions in the myocardium of the 5 groups of mice. (F) Quantification of the protein expressions of Col I, Col III, TGF-β1, Bax/Bcl-2 and Cl-caspase3 in the myocardium of the 5 groups of mice. n=5 per group. Ang IV: angiotensin IV; Cl-caspase3: cleaved caspase 3; Col I: collagen I; Col III: collagen III; DM: diabetes mellitus; NC: normal control. *p < 0.05, **p < 0.01, ***p < 0.001.