Table 1.

Effects of Ang IV on left ventricular function and dimension in 5 groups of mice of the first part in vivo experiment

	NC	DM	Low-dose Ang IV	Medium-dose Ang IV	High-dose Ang IV
LVEF (%)	78.00 ± 2.90***	49.66 ± 3.94	59.27 ± 2.64##	61.73 ± 2.32*#	72.31 ± 1.98***
FS (%)	49.30 ± 2.58***	30.29 ± 3.56	34.24 ± 1.79#	36.73 ± 1.66	43.02 ± 2.02**
E/A	1.52 ± 0.07**	0.97 ± 0.14	1.12 ± 0.09#	1.31± 0.08	1.47 ± 0.05**
E'/A'	1.71 ± 0.11***	0.79± 0.14	1.02 ± 0.14	1.08 ± 0.11	1.33 ± 0.08*
LVEDD (mm)	2.78 ± 0.04**	3.45 ± 0.17	3.35 ± 0.12#	3.21 ± 0.10	2.85 ± 0.10**

Ang IV: Angiotensin IV; DM: diabetes mellitus; E/A: the ratio of the early to late diastolic mitral inflow velocities; E'/A': the ratio of the early to late diastolic mitral annular velocities; FS: fractional shortening; LVEF: left ventricular ejection fraction; LVEDD: left ventricular end-diastolic diameter; NC: normal control. *p < 0.05, **p < 0.01, ***p < 0.001 vs. DM group; ^#p < 0.05, ^##p < 0.01 vs. High-dose Ang IV group. n ≥ 8 per group.