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. 2021 Aug 12;11(18):8813–8835. doi: 10.7150/thno.62521

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Correlation between pyroptosis and the tumor immune microenvironment. (A) Downregulation of perforin and granzyme B and reduced infiltration of NK cells and CTLs were observed in the GSDME^-/- cancer cell line microenvironment. (B) Caspase-3-mediated pyroptosis in cancer cells is induced through perforin and granzyme B secreted by CAR-T cells. (C) The administration of NP-GSDMA3 and Phe-BF3 can induce GSMDA3-mediated pyroptosis in cancer cells and contribute to increased infiltration of immune cells, including CD4⁺ and CD8⁺ lymphocytes and M1 macrophages, and reduced infiltration of CD4⁺ regulatory T lymphocytes.