kdm5c knock out elicit ccRCC-specific metabolic phenotype. A, Western blot analysis of the KDM5C protein level in renal tissues of wild-type and Kdm5c-/- mice. B-D, Hematoxylin and eosin (B), Ki67 immunohistochemical (C), and PAS (D) staining in the renal cortex from indicated mice, Scale bar, 20 µm. E, PAS staining of indicated 769-P cell lines. F-H, The intracellular glycogen content of indicated engineered 769-P (F), ACHN (G), A498 (H) cell lines. P values were calculated using paired t-test. Data represent means ± SD. Data are representative of three independent experiments.