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A number of genomic alterations were identified in RCC4 cells through comparing the exome sequencing results of HK2 and RCC4 cells
| Gene | Mutation |
|---|---|
| KDM5C | 1 frameshift deletion |
| VHL | 1 missense |
| USP34 | 1 splicing,1synonymous |
| TBP | 1 nonframeshift deletion,3 synonymous |
| FOXE1 | 1 nonframeshift deletion, 2 synonymous |
| EP400 | 1 nonframeshift insertion, 1 missense |
| POLG | 1 nonframeshift deletion |
| CHD2 | 1 frameshift deletion, 2 synonymous |
