Table 1.

Summary of IHC staining results for mice implanted with EBV⁺ human B-cells and treated with IgG1 control monoclonal antibody that developed lymphoma-like growths.

Immunohistochemistry								Circulating plasma levels
Mouse #	Euthanized (Days post-cell implantation)	Tissue section	Human CD3	Human CD19	EBV LMP1	Human Ig κ LC	Human Ig λ LC	Human Ig κ FLC (μg/l)	Human Ig λ FLC (μg/l)
1	Day 58	Spleen (white spots)	+	+	+	+	+	402	18,544
		Tumor, liver	+	+	+	+	+
		Tumor, inguinal lymph node	Negative	+	+	+	+
		Tumor near the gastrointestinal tract	+	+	+	+	+
2	Day 58	Tumor, mesenteric LN	Negative	+	+	+	+	623	3,120
		Tumor, liver	Negative	+	+	+	+
3	Day 65	Spleen (white spots)	Negative	+	+	+	+	3,854	8,363
		Tumor, kidney	Negative	+	+	+	+
		Tumor, skin	Negative	+	+	+	+
		Tumor, liver	+	+	+	+	+
4	Day 99	Spleen (white spots)	Negative	+	+	+	+	111,110	1,649
		Liver (white spots)	Negative	+	+	+	Negative
5	Day 50	Subcutaneous tumor mass in the back of the neck	Negative	+	+	+	+	305	3,855
6	Day 64	Tumor, kidney	Negative	+	+	+	+	8,956	1,010
7	Day 69	Subcutaneous tumor mass in the back	Negative	+	+	+	+	1,214	2,589
		Tumor, inguinal lymph node	Negative	+	+	+	+
8	Day 69	Tumor, kidney	Negative	+	+	+	+	6,255	963
9	Day 85	Spleen (white spots)	+	+	+	Negative	+	778	150,319
		Liver (white spots)	+	+	+	Negative	+
10	Day 118	Spleen (white spots)	Negative	+	+	+	Negative	12,982	1,574
		Liver (white spots)	Negative	+	+	+	Negative