Table 4.
Stratified analysis by sex for top associated metabolites
| Female, 125 pairs | Male, 125 pairs | ||||
|---|---|---|---|---|---|
| Metabolites | OR (95%CI) | P | OR (95%CI) | P | P interaction |
| orotate | 1.97 (1.31–2.97) | 0.00124 | 1.69 (1.13–2.52) | 0.01091 | 0.34856 |
| 1-(1-enyl-palmitoyl)-GPE (P-16:0) | 1.98 (1.42–2.75) | 5.35×10−5 | 1.05 (0.69–1.58) | 0.83091 | 0.01519 |
| sphinganine | 2.73 (1.82–4.08) | 1.11×10−6 | 0.79 (0.52–1.19) | 0.25627 | 6.24×10−6 |
| 1-(1-enyl-stearoyl)-GPE (P-18:0) | 2.07 (1.46–2.93) | 4.52×10−5 | 0.98 (0.65–1.50) | 0.93559 | 0.00796 |
| glycerophosphoethanolamine | 2.04 (1.43–2.91) | 8.93×10−5 | 1.00 (0.65–1.55) | 0.98755 | 0.02216 |
| 5alpha-pregnan-3beta_20beta-diol monosulfate | 1.66 (1.22–2.26) | 0.00127 | 1.30 (0.84–2.02) | 0.2349 | 0.49745 |
| N6-methyllysine | 1.50 (1.12–2.02) | 0.00645 | 1.17 (0.82–1.68) | 0.38973 | 0.37326 |
| 3-hydroxypyridine sulfate | 0.74 (0.53–1.02) | 0.06896 | 0.64 (0.42–0.99) | 0.04677 | 0.7874 |
| 1-(1-enyl-oleoyl)-2-docosahexaenoyl-GPE (P-18:1/22:6) | 1.63 (1.09–2.43) | 0.01655 | 1.44 (1.04–1.98) | 0.02592 | 0.52726 |
| 1-palmitoyl-GPC (16:0) | 2.32 (1.57–3.42) | 2.25×10−5 | 0.77 (0.51–1.15) | 0.20017 | 1.41×10−4 |
| 1-(1-enyl-palmitoyl)-GPC (P-16:0) | 2.02 (1.41–2.88) | 1.18 ×10−4 | 0.94 (0.66–1.32) | 0.70482 | 0.00647 |
| quinate | 0.63 (0.46–0.88) | 0.00578 | 0.85 (0.57–1.28) | 0.44122 | 0.20962 |
| 1-stearoyl-GPC (18:0) | 1.99 (1.39–2.85) | 1.57×10−4 | 0.86 (0.57–1.30) | 0.46564 | 0.00556 |
| methylmalonate (MMA) | 1.32 (0.95–1.84) | 0.10169 | 1.54 (1.06–2.24) | 0.02225 | 0.67982 |
| N-(2-furoyl) glycine | 0.71 (0.52–0.98) | 0.0342 | 0.73 (0.46–1.14) | 0.16366 | 0.76516 |
| 5alpha-pregnan-diol disulfate | 1.62 (1.14–2.28) | 0.00655 | 1.26 (0.85–1.87) | 0.24925 | 0.55568 |
| glutamate | 1.87 (1.34–2.62) | 2.64×10−4 | 0.71 (0.45–1.13) | 0.14598 | 0.0055 |
| cysteine | 0.74 (0.54–1.02) | 0.0663 | 0.65 (0.45–0.96) | 0.03059 | 0.9852 |
The covariates listed in Table 2 were included in the regression analysis.