Table 5.
Odds ratios and 95% CIs for the association between duration of genital powder use and ovarian cancer, overall and by race, stratified by histotype
| All cases | High-grade serous | All other histotypes | |||||
|---|---|---|---|---|---|---|---|
| Duration of usea | Controls (%) | Cases (%) | MVb OR (95% CI)c |
Cases (%) | MVb OR (95% CI)c |
Cases (%) | MVb OR (95% CI)c |
| All participants | |||||||
| No genital use | 5403 (69.5) | 2374 (71.1) | 1.00 | 1452 (70.4) | 1.00 | 900 (72.1) | 1.00 |
| ≤20 years | 1443 (18.6) | 534 (16.0) | 1.43 (1.22–1.68) | 334 (16.2) | 1.42 (1.17–1.71) | 198 (15.9) | 1.44 (1.16–1.78) |
| >20 years | 924 (11.9) | 483 (12.9) | 1.28 (1.08–1.51) | 277 (13.4) | 1.32 (1.09–1.60) | 151 (12.1) | 1.19 (0.94–1.50) |
| ptrendd | 0.97 | 0.71 | 0.58 | ||||
| African Americans | |||||||
| No genital use | 756 (67.7) | 398 (66.0) | 1.00 | 255 (65.2) | 1.00 | 141 (67.1) | 1.00 |
| ≤20 years | 196 (17.6) | 106 (17.6) | 1.44 (1.06–1.95) | 67 (17.1) | 1.53 (1.07–2.18) | 39 (18.6) | 1.29 (0.83–2.00) |
| >20 years | 164 (14.7) | 99 (16.4) | 1.06 (0.78–1.44) | 69 (17.7) | 1.19 (0.84–1.69) | 30 (14.3) | 0.83 (0.52–1.34) |
| ptrendd | 0.19 | 0.39 | 0.28 | ||||
| Whites | |||||||
| No genital use | 4647 (69.8) | 1976 (72.2) | 1.00 | 1197 (71.6) | 1.00 | 759 (73.1) | 1.00 |
| ≤20 years | 1247 (18.7) | 428 (15.6) | 1.42 (1.17–1.71) | 267 (16.0) | 1.35 (1.08–1.69) | 159 (15.3) | 1.47 (1.15–1.88) |
| >20 years | 760 (11.4) | 333 (12.2) | 1.40 (1.14–1.72) | 208 (12.4) | 1.40 (1.11–1.77) | 121 (11.7) | 1.36 (1.03–1.80) |
| ptrendd | 0.33 | 0.26 | 0.83 | ||||
Duration of use variable includes the following study sites: AACES, CCCS, NCOCS, LACOCS, WHI
MV=Multivariable
Adjusted for age (continuous), education (high school graduate/GED or less, some college, college graduate, graduate/professional school), duration of OC use (months, continuous), family history of breast cancer (no, yes, family history of ovarian cancer (no, yes), tubal ligation (yes, no), full term pregnancies (number of pregnancies ≥ 6 months, continuous), hysterectomy (no, yes), interview year (continuous), BMI (<25.0, 25.0–29.9, 30.0–34.9, ≥35.0), menopausal (premenopausal, postmenopausal), smoking (ever, never), study site (AACES, CCCS, NCOCS, LACOCS, WHI)
Determined using category median values