Figure 10.

In Novel Object Recognition (NOR), young and old mice show novelty discrimination, but propranolol blocks discrimination in young mice and impairs discrimination in old mice. A) NOR experimental design. B-D) 3 month (3M) but not 18M mice move greater distance during the testing phase of NOR relative to habituation and training. E-G) Both 3M and 18M mice show preference for novel object in terms of % time interaction. F,G) Propranolol impairs novel object preference in 3M and 18M mice, and G) mabuterol impairs novel object preference in 18M mice. * indicates p < .05, ** p < .01, *** p < .001; Sidak’s posthoc after two-way ANOVA.