Figure 8.

Mabuterol decreased distance moved in Y-maze and increased time spent in novel versus familiar arms in young versus aged mice respectively. A) Y-Maze Forced Alternation experimental design. B) 18 month (18M) mice tended to move less than 3M mice during Y-Maze forced alternation testing. C,D) Mabuterol decreased distance moved in both 3M and 18M mice and D) propranolol tended to increase distance moved in 18M mice, but increase did not reach significance. E) 3M mice explore both novel and familiar arms, while 18M mice show a preference for the familiar arm. F) Mabuterol increases time spent in the novel arm in 3M mice. G) Propranolol decreases preference for familiar arm in 18M mice. H) 18M mice but not 3M mice had more entries into the familiar versus novel arms and J) propranolol blocked the increased number of entries into the familiar arm in 18M mice. * indicates p < .05, **p < .01, ***p < .001; Dunnett’s posthoc after one-way ANOVA (C, D), or Sidak’s posthoc after two-way ANOVA (E-J).