Fig. 4 –

BCR-free survival in groups stratified by CAI among the 749 patients in the validation set. (A) Using a single threshold, the group with CAI ≤0.10 had significantly better survival than the group with CAI >0.10. (B) Using multiple thresholds, the group with CAI between 0 and 0.05 had significantly better survival than the other groups; the other groups had no significant differences in survival. (C) Validation set patients stratified by LPM. (D) LPM high-risk patients further stratified by CAI >0.10.

BCR = biochemical recurrence; CAI = cribriform area index; HR = hazard ratio; LPM = lumen-based prognosis model.