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. 2021 Aug 1;25(17):8442–8453. doi: 10.1111/jcmm.16805

FIGURE 1.

FIGURE 1

Expression of BUB1 protein in osteosarcoma (OS) tissues and cell lines. A, Representative images of different staining intensities of BUB1 protein in OS and normal bone tissues. B, Immunohistochemistry scores of OS tissues. C, Representative images showing the up‐regulated expression of BUB1 protein in Saos2, U2OS and 143B cells; the ratio calculation was detected by using grey analysis. D, Significant differences in progression‐free survival (PFS) (p < 0.001) and overall survival (p < 0.001) time between OS patients with high and low expression of BUB1. E, Cell viability was markedly reduced by incubating cells with BAY 1816032 for 72 h in Saos2 and U2OS cells.