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Effect of BUB1 inhibition on the cell apoptosis and apoptosis‐related proteins. A, B, Increased total apoptosis rate in Saos2 and U2OS cells after treatment with different concentrations of BAY 1816032. C, D, Increased total apoptosis rate in Saos2 and U2OS cells with BUB1 gene knockdown. E, F, Expression of P53, caspase 3 and Bcl‐2 proteins in Saos2 and U2OS cells following treatment with BAY 1816032 and BUB1 gene knockdown. **p < 0.01, ***p < 0.001.
