TABLE 2.

Univariate analysis of BUB1 expression and osteosarcoma patient survival

Characteristics	Case number	Progression‐free survival (months)				Overall survival (months)
		Mean	SD	95% CI	p‐value	Mean	SD	95% CI	p‐value
Sex
Male	27	54.015	7.943	38.447–69.583	0.134	75.107	6.681	62.012–88.202	0.293
Female	14	33.857	9.586	15.068–52.646		60.516	10.726	39.493–81.539
Age (years)
<18	14	34.357	8.839	17.033–51.682	0.225	57.643	9.062	39.880–75.405	0.216
≥18	27	53.333	8.101	37.454–69.212		76.005	7.012	62.262–89.749
Tumour size (cm)
<8	24	47.979	8.262	31.785–64.173	0.821	69.685	7.759	54.477–84.893	0.880
≥8	17	46.412	10.024	26.765–66059		70.886	8.737	53.762–88.011
Tumour location
Tibia or femur	23	57.130	8.820	39.843–74.418	0.053	78.026	7.194	63.926–92.127	0.080
Others	18	34.593	8.174	18.571–50.615		59.944	8.804	42.688–77.201
Histologic subtype
Conventional	34	48.603	7.017	34.850–62.356	0.717	68.804	6.365	56.329–81.280	0.839
Others	7	40.286	14.703	11.467–69.105		71.667	13.220	45.756–97.577
Enneking staging
I‐IIA	10	57.375	13.322	31.264–83.486	0.481	76.614	10.986	55.083–98.146	0.706
IIB	31	41.161	7.177	30.094–58.229		68.846	6.772	55.572–82.120
Response to chemotherapy
Poor	17	16.471	2.518	11.536–21.405	< 0.001	38.752	6.300	26.404–51.100	< 0.001
Good	24	68.946	8.208	52.859–85.034		86.052	5.680	74.919–97.185
Distant metastasis
Yes	15	16.267	2.783	10.811–21.722	< 0.001	42.071	5.469	31.352–52.791	0.002
No	26	65.027	8.039	49.271–80.784		83.228	6.689	70.117–96.338
BUB1 expression
High	16	13.563	1.793	10.047–17.078	< 0.001	33.707	5.297	23.324–44.089	< 0.001
Low	25	68.709	7.745	53.528–83.889		88.780	5.312	78.369–99.191