FIGURE 2.

Cytotherapy of MSCs ameliorate hyperoxia‐induced inflammation and angiogenesis‐associated cytokine level changes in plasma and lung tissues in BPD rats. The plasma levels of proinflammatory and angiogenesis cytokines were measured including TNF‐α (A), VEGFA (B) and ET1 (C). Hyperoxia induced increase of TNF‐α and ET1 and decrease of VEGFA, while cytotherapy of MSCs ameliorated these changes. Some other proinflammatory cytokines were measured in lung tissue lysis, including TNF‐α (D), IL1B (E) and IL6 (F). Cytotherapy of MSCs also ameliorated hyperoxia‐induced proinflammatory cytokine increase. n = 5; *, p < 0.05 compared with the BPD group; &, p < 0.05 compared with the BPD+AF‐MSC group; #, p < 0.05 compared with the BPD+UC‐MSC group