FIGURE 6.

Effect of circTLK1/PARP1 axis on oxidative mtDNA damage–mediated cardiomyocyte apoptosis in septic rats. (A) and (B) PARP1 and HMGB1 expression levels in the myocardial tissues. C, The apoptosis in myocardial tissues. D, The protein levels of Bcl‐2, Bax and cleaved caspase‐3 in myocardial tissues were assessed. The levels of MDA (E) and 8‐OHdG (F) in myocardial tissues were detected. G, The mtDNA copy number in myocardial tissues was determined. H, The mtDNA transcript levels (ND1, CytB and ATP6) in myocardial tissues were determined. All results from three independent experiments were expressed as mean  ± SD. *P < .05; **P < .01; ***P < .001 vs the indicated group