FIGURE 8.

Inhibition of miR‐17‐5p reverses the inhibitory effect of circTLK1 knockdown on oxidative mtDNA damage‐mediated apoptosis. A, The apoptosis of HCM cells from multiple groups was determined. The levels of ROS (B), MDA (C) and SOD (D) in HCM cells were detected. E, The 8‐OHdG level in HCM cells was assessed. F, The mtDNA copy number in HCM cells was evaluated. G, The mtDNA transcript levels (ND1, CytB and ATP6) in HCM cells were detected. All results from three independent experiments were expressed as mean  ± SD. *P < .05; **P < .01; ***P < .001 vs the indicated group