Table 4.

Summary of significant pathways (FDR ≤0.05) in peripheral blood mononuclear cells between: A) HIV/HCV-coinfected at week 36 after SVR (HIV/HCV-f) versus HIV/HCV-coinfected at baseline (HIV/HCV-b). B) HIV/HCV-coinfected at week 36 after SVR (HIV/HCV-f) versus HCV-monoinfected at week 36 after SVR (HCV-mono-f); C) HIV/HCV-coinfected at week 36 after SVR (HIV/HCV-f) and HIV-monoinfected (HIV-mono).

A) HIV/HCV-f versus HIV/HCV-b				B) HIV/HCV-f versus HCV-mono-f				C) HIV/HCV-f versus HIV-mono
KEGG	Hits	Genes	q-values	KEGG	Hits	Genes	q-values	KEGG	Hits	Genes	q-values
Cytokine-cytokine receptor interaction	4	CCL2, CCL7, CCL8, CXCL11	0.021	Primary immunodeficiency	3	CD8A, CD8B, TNFRSF13C	0.009	Cytokine-cytokine receptor interaction	9	CCL20, CXCL3, CXCL8, EDAR, IL1A, PF4, PF4V1, TNFSF15, TNFSF9	<0.001
Viral protein interaction with cytokine and cytokine receptor	4	CCL2, CCL7, CCL8, CXCL11	0.001					Viral protein interaction with cytokine and cytokine receptor	5	CCL20, CXCL3, CXCL8, PF4, PF4V1	0.002
Chemokine signaling pathway	4	CCL2, CCL7, CCL8, CXCL11	0.006					Chemokine signaling pathway	6	CCL20, CXCL3, CXCL8, PARD3, PF4, PF4V1	0.003
Hepatitis C	3	IFIT1, IFIT1B, MX1	0.047					Rheumatoid arthritis	4	CCL20, CXCL3, CXCL8, IL1A	0.017

q-values, p values corrected for multiple comparisons using Benjamini and Hochberg procedure. In red, upregulated genes in HIV/HCV-f group; in green, downregulated genes in HIV/HCV-f group.

KEGG, Kyoto Encyclopedia of Genes and Genomes; HIV, human immunodeficiency virus; HCV, hepatitis C virus; HIV/HCV-b, HIV/HCV-coinfected patients at baseline; HIV/HCV-f, HIV/HCV-coinfected patients 36 weeks after SVR; HCV-mono-f, HCV-monoinfected at week 36 after SVR; HIV-mono, HIV-monoinfected patients.