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. 2021 Aug 23;12:710750. doi: 10.3389/fimmu.2021.710750

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Copyright © 2021 Shen, Zhang, Xie, Chen, Li, Zheng, Chai, Wang, Zang and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peripheral Treg cell subsets and function are altered in patients with allergic asthma. (A, B) CCR6 vs. IL-17 expression of CD3⁺CD8^-CD25⁺Foxp3⁺ Treg cells from the healthy donor (n =12) and patients with asthma (n = 15) analyzed with FACS. Representative dot plots are shown. (C, D) ICOS vs. CCR6 expression of CD3⁺CD8^-CD25⁺Foxp3⁺ Treg cells from the healthy donor (n =12) and patients with asthma (n = 15) analyzed using FACS. Representative dot plots are shown. (E, F) IL-10⁺Foxp3⁺ Treg cells from the healthy donor (n = 12) and patients with asthma (n =15) analyzed with FACS. Representative dot plots are shown. (G, H) TGF-β⁺Foxp3⁺ Treg cells from the healthy donor (n = 12) and patients with asthma (n = 15) analyzed using FACS. Representative dot plots of are shown. Bars represent the mean ± SEM. *P < 0.05, ***P < 0.001; ns, not significant.