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. 2021 Aug 23;12:738590. doi: 10.3389/fphar.2021.738590

FIGURE 2.

FIGURE 2

Anesthesia and surgery-induced cognitive impairments were ameliorated by clemastine treatment. (A) Total distance in the open field test among four groups. (B) Time spent in the center of open field test among four groups. (C) Context test in the fear conditioning test among four groups. (D) Tone test in the fear conditioning test among four groups. (E) Performance during the training phase of the Barnes maze. (F, G) Performance during the testing phase of Barnes maze. (H, I) Representative movement traces on day 1 and day 8 of the Barnes maze test phase. The data are presented as mean ± S.D. (n = 20 mice per group). * p < 0.05 compared with the CON group. ***p < 0.005 compared with the CON group. ****p < 0.001 compared with the CON group. # p < 0.05 compared with the PND group. #### p < 0.001 compared with the PND group. ∨ p < 0.05 compared with the CON + CLE group. ∨∨ p < 0.01 compared with the CON + CLE group. ∨∨∨∨ p < 0.001 compared with the CON + CLE group. &&&& p < 0.001 compared with the day 1 in CON group. @@@@ p < 0.001 compared with the day 1 in CON + CLE group. $ p < 0.05 compared with the first day in PND group. ^ p < 0.05 compared with the first day in PND + CLE group.