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. 2021 Aug 23;15:701308. doi: 10.3389/fnins.2021.701308

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Copyright © 2021 Silva, Morr, Mueller, Koch, Boehm-Sturm, Rodriguez-Sillke, Kunkel, Tzschätzsch, Kühl, Schnorr, Taupitz, Sack and Infante-Duarte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain mechanical properties in Gd-enhanced lesions during EAE. (A) Representative T1-weighted image acquired before (left) and after GBCA (right) injection (corresponding GBCA mask overlaid) shows Gd-enhancing lesions near the left hippocampal artery. (B) GBCA mask overlaid on averaged MRE maps of stiffness (shear wave speed) and fluidity (loss angle). (C) Stiffness represented by shear wave speed (c) was reduced during EAE (p = 0.0183; paired t-test) whereas tissue fluidity (ϕ) was unchanged (p = 0.3683; paired t test). n = 19; mean, min/max; *<0.05. Of note, ventricles are excluded from our analysis since MRE cannot be performed in fluid compartments.