Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 23;15:701308. doi: 10.3389/fnins.2021.701308

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Silva, Morr, Mueller, Koch, Boehm-Sturm, Rodriguez-Sillke, Kunkel, Tzschätzsch, Kühl, Schnorr, Taupitz, Sack and Infante-Duarte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Brain mechanical properties of areas accumulating Eu-VSOPs during EAE. (A) Exemplary image of a mask comprising Eu-VSOP accumulation overlaid on T2*-weighted image prior (left) and post Eu-VSOP (right) injection. (B) Shear wave speed map (c in m/s) and loss angle map (ϕ in rad). (C) There is a significant reduction in stiffness in sites with Eu-VSOP accumulation compared to non-hypointense areas (p = 0.0235, paired t-test). Fluidity of brain tissue in these areas, marked by ϕ, is not affected (p = 0.1168, paired t-test). n = 8, mean, min/max; *<0.05. Of note, ventricles are excluded from our analysis since MRE cannot be performed in fluid compartments.