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. 2021 Aug 23;15:701308. doi: 10.3389/fnins.2021.701308

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Copyright © 2021 Silva, Morr, Mueller, Koch, Boehm-Sturm, Rodriguez-Sillke, Kunkel, Tzschätzsch, Kühl, Schnorr, Taupitz, Sack and Infante-Duarte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visualization of brain inflammation induced by EAE using IMC. (A) Brain section of a healthy control (naïve) mouse at the third ventricles (left) and brain stem and hippocampal formation (right). (B) Extensive inflammation during EAE can be visualized by infiltration of CD45⁺ cells (cyan), astrogliosis (GFAP, green) and activated microglia (Iba-1, white) (white arrows). Neurons (NeuN—magenta), astrocytes (GFAP—green), endothelial cells (CD31—yellow), nuclei (histone H3—blue), microglia (Iba-1—white), leucocytes (CD45—cyan). Scale bar: 100 μm.