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. 2021 Aug 23;15:701308. doi: 10.3389/fnins.2021.701308

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Copyright © 2021 Silva, Morr, Mueller, Koch, Boehm-Sturm, Rodriguez-Sillke, Kunkel, Tzschätzsch, Kühl, Schnorr, Taupitz, Sack and Infante-Duarte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological visualization of Eu-VSOP distribution by IMC. (A) Magnetic particle accumulation in the perivascular space with strong leukocyte infiltrate (arrowheads) located between brain stem and hippocampal formation. (B) In the third ventricle, particles can be found in the choroid plexus and are associated with perivascular inflammation (arrows). Eu-VSOPs (red dots), neurons (NeuN—magenta), astrocytes (GFAP—green), endothelial cells (CD31—yellow), nuclei (histone H3—blue), microglia (Iba-1—white), leucocytes (CD45—cyan). Scale bar: 50 mm.