Table 2.
Predictors of elevated ALT and ALP and liver injury in hospitalized patients with COVID-19
| Variables | Fully adjusted regression model | |||||
|---|---|---|---|---|---|---|
| Peak ALT beta (95% CI) | p-value | Peak ALP beta (95% CI) | p-value | Severe ALI OR (95% CI) | p-value | |
| WBC count (per mL3) | 9.7 (6.7–12.6) | < 0.001 | 2.8 (2.0–3.5) | < 0.001 | 1.0 (1.01–1.1) | 0.015 |
| Hemoglobin (g/dL) | NS | − 6.5 (− 9.1 to − 3.9) | < 0.001 | NS | ||
| Platelet count (per 109/L) | NS | − 0.1 (− 0.2 to − 0.02) | 0.013 | 1.0 (0.98–1.0) | 0.001 | |
| African-American race | NS | NS | 2.5 (1.01–6.1) | 0.047 | ||
| Hispanic ethnicity | NS | 26.5 (10.8–42.2) | 0.001 | NS | ||
| BMI (per unit) | NS | − 1.3 (− 2.0 to − 0.6) | < 0.001 | NS | ||
| AKI | NS | 19.9 (2.3–37.4) | 0.027 | NS | ||
| ESRD | 106.3 (27.6–185.1) | 0.008 | NS | NS | ||
| Vasopressor requirement | 80.1 (21.5–138.8) | 0.007 | 18.8 (3.7–33.9) | 0.015 | 4.2 (1.4–12.5) | 0.009 |
Abbreviations: AKI = acute kidney injury, ALI = acute liver injury, ALP = alkaline phosphatase, ALT = alanine aminotransferase, BMI = body mass index, CI = confidence interval, ESRD = end-stage renal disease, OR = odds ratio, NS = not significant, WBC = white blood cell