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MAPT R406W carriers have increased CSF pT217/T217 without Amyloid pathology. (A) All samples (n = 252) were plotted to quadrant analyses using the cutoffs calculated in the WashU‐A cohort (CSF Aβ 42/40 cutoff = 0.086, CSF pT217/T217 cutoff = 4.76). (B–E) Pie charts showing the number of participants in each clinically classified group for each quadrant: II (B), I (C), III (D), and IV (E). CSF, cerebrospinal fluid.
