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. 2021 Jul 27;8(9):1831–1844. doi: 10.1002/acn3.51428

Figure 3.

Figure 3

Receiver operating characteristic (ROC) nonparametric analysis to evaluate the performance of Nf and Abs/ICs analytes in the discrimination of ALS from healthy controls and phenotypic variants of the disease (plots indicate sensitivity against 1‐specificity). (A) Nf‐L protein plasma levels strongly discriminate ALS patients from HC (AUC = 0.93, p < 0.0001) and (B) ALS‐F from ALS‐S (AUC = 0.89, p < 0.0001). (C) Nf‐H proteins plasma levels provide a moderate separation of ALS from HC (AUC = 0.72, respectively, p = 0.0001). (D) Nf‐H Abs expression levels separate ALS from HC (AUC: 0.68; p < 0.0001). (E) Nf‐L ICs expression shows a fair discrimination of ALS‐F from C9+ve ALS (AUC = 0.78, p < 0.0001) and (F) ALS‐F from HC (AUC = 0.72; p < 0.0001).