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. 2021 Aug 23;9:689006. doi: 10.3389/fchem.2021.689006

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Copyright © 2021 Lozada, Barlow, Gonzalez, Lubin-Germain and Ballet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of HCV glycoproteins E1 and E2. E1 is composed of an N-terminal domain (NTD, yellow), a putative fusion peptide (PFP, red), a conserved region (CR, blue), and a transmembrane domain (TMD, black). E2 is composed of two hypervariable regions (HVR1 and HVR2, orange) and a transmembrane region (TMD, black). The glycosylation site N250 is specific to genotype 1b/6.