TABLE 5.

Sequence alignment of the region (265–298) across various HCV genotypes (Li et al., 2009). In bold are represented the highly conserved residues. In green, amino acids modified by mutagenesis. Underlined conserved motives GDLC and VFLVG.

Genotype	Sequence
HCV1a (H77)	LVGSATLCSALYVGD L CGSVFLVG QLFTFSPRHH
HCV1b (BK)	LVGAAAFCSAMYVGD L CGSVFLVSQLFTFSPRRH
HCV2a (BEBE1)	IVMSATLCSALYVGDVCGALMIAAQVVVVSPQHH
HCV5a (SA13)	LAGGAALCSALYVGDACGAVFLVG QMFTYSPRRH
HCV3a (NZL1)	LVGAATMCSALYVGDMCGAVFLVGQAFTFRPRRH
HCV6a (6a33)	LAGAAVVCSSLYIGD L CGSLFLAGQLFTFQPRRH
HCV4a (ED43)	MVGAATVCSGLYIGD L CGGLFLVGQMFSFRPRRH