TABLE 8.

Alignment of segment 416–445 from various genotypes of HCV. In bold are represented the highly conserved residues. In green, amino acids modified by mutagenesis. Underlined, the GxxxG motif. In red, glycosylation sites.

Genotype	Sequence
HCV1a (H77)	TNGSWHINSTALNCNESLNTG WL A G LFYQH
HCV1b (BK)	TNGSWHINRTALNCNDSLQTGFLAALFYTH
HCV2a (BEBE1)	TNGSWHINRTALNCNDSLETGFLAALFYTS
HCV5a (SA13)	TNGSWHINRTALNCNDSLQTG FV A G LLYYH
HCV3a (NZL1)	TNGSWHINSTALNCNESINTG FI A G LFYYH
HCV6a (6a33)	NGSSWHINRTALNCNDSLQTGFLASLFYVR
HCV4a (ED43)	SNGSWHINRTALNCNDSLNTGFLASLFYTH