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. 2021 Aug 23;11:733763. doi: 10.3389/fonc.2021.733763

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Copyright © 2021 Xu, Zhou, Wang, Tang, Hu, Wang, Chen, Zheng, Yan and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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tRF-Glu-TTC-027 influenced the expression of related proteins in the MAPK signaling pathway. (A, B) tRF-Glu-TTC-027 inhibitor could upregulate the expression of p-p38 and c-Myc in HGC-27, and p-ERK, p-p38, and c-Myc in NCI-N87. p38 MAPK-IN could suppress the expression of p-ERK, p-p38, Elk1, p-Elk1, c-Myc, cyclinD1 in HGC-27 and NCI-N87. (C) tRF-Glu-TTC-027 mimics could inhibit the expression of p-ERK, p-JNK, p-p38, c-Myc, CDK2, p-ELK1 in NCI-N87, and p38, p-p38, c-Myc, p-ELK1 in HGC-27.