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. 2021 Aug 23;12:628950. doi: 10.3389/fphar.2021.628950

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Copyright © 2021 Xu, Tang, He, Cai, Wang, Zhang, Wu, Qian, Zhang, Chai, Chen, Xu, Ji, Xiao and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DL-NBP treatment ameliorates diabetes-induced renal fibrosis. (A–D) Immunohistochemical staining (original magnification × 400) and quantification of α-SMA, collagen I, and collagen III in kidney of mice from each group (n = 3). Scale bar = 20 μm. (E–H) Western blotting and quantification of collagen I and collagen III from the renal tissue of each group (n = 3). Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. db/m control group; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. db/db mice. α-SMA, α-smooth muscle actin.