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. 2021 Aug 23;12:628950. doi: 10.3389/fphar.2021.628950

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Copyright © 2021 Xu, Tang, He, Cai, Wang, Zhang, Wu, Qian, Zhang, Chai, Chen, Xu, Ji, Xiao and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DL-NBP restores the function of RAS and blocks VEGF overexpression. (A–D) Western blotting and quantification analysis of AT1, ACE, and VEGF in kidney of mice from each group (n = 3). Protein expression was normalized to the expression of β-actin. (E–G) Immunohistochemical staining of VEGF (brown positive point) in kidney of mice from each group (original magnification × 400) (n = 3). Scale bar = 20 μm. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001 vs. db/m control; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. db/db mice. AT1, angiotensin II-related proteins angiotensin II receptor type 1; ACE, angiotensin II generating enzyme; VEGF, vascular endothelial growth factor.