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. 2021 Aug 23;12:710947. doi: 10.3389/fendo.2021.710947

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Copyright © 2021 Mitrofanova, Perminova, Ryzhkova, Sukhotskaya, Bairov and Nikitina

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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¹⁸F-fluoro-L-dihydroxyphenylalanine (¹⁸F-DOPA)-positron emission tomography images (MIP) of pancreas. (A) The patient with diffuse congenital hyperinsulinism: homogenic 18F-DOPA uptake in pancreatic tissue. (B) The patient with focal form of congenital hyperinsulinism: focal intense ¹⁸F-DOPA -PET accumulation in the pancreatic body and physiological ¹⁸F-DOPA uptake in the pancreatic head. (C) False positive result of ¹⁸F-fluoro-L-dihydroxyphenylalanine (18F-DOPA)-positron emission tomography. Histologically proven atypical form imitates focal form of congenital hyperinsulinism with focus of adenomatous hyperplasia in the pancreatic head (arrowhead). In this case, we have found a disagreement between imaging (focal) and pathology (atypical).