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. 2021 Aug 23;12:710947. doi: 10.3389/fendo.2021.710947

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Copyright © 2021 Mitrofanova, Perminova, Ryzhkova, Sukhotskaya, Bairov and Nikitina

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The proportion of cells with enlarged nuclei among endocrinocytes in the field of view (percentage), frozen sections. Data are presented as M ± SD. (*) - the difference in comparison with the control is statistically significant at p <0.05; (#) - the difference in comparison with tissue of the pancreas outside the lesion in the focal form is statistically significant at p <0.01; (^) - the difference compared with the zone of adenomatous hyperplasia is statistically significant at p <0.01. Note: focal node - zone of adenomatous hyperplasia in focal form; focal not node - pancreatic tissue outside the zone of adenomatous hyperplasia; diffuse - diffuse form.